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A fluorometric-HPLC assay for quantitating the binding of benzo[a]pyrene metabolites to DNA

✍ Scribed by R.O. Rahn; S.S. Chang; J.M. Holland; L.R. Shugart


Book ID
115755940
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
460 KB
Volume
109
Category
Article
ISSN
0006-291X

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## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy