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602 Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer

✍ Scribed by Marchetti, ; Doglioni, C.; Barbareschi, M.; Buttitta, F.; Pellegrini, S.; Caffo, O.; Gaeta, P.; Chella, A.; Angeletti, C.A.; Dalla Palma, P.; Bevilacqua, G.

Book ID
122553196
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
152 KB
Volume
18
Category
Article
ISSN
0169-5002

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Cyclin D1 and retinoblastoma susceptibil
Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer
✍ Antonio Marchetti; Claudio Doglioni; Mattia Barbareschi; Fiamma Buttitta; Silvia πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 256 KB πŸ‘ 2 views

Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr