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9060 Cyclin D1 and Non-Small cell lung cancer – a role of CCND1 gene variants in lung carcinogenesis

✍ Scribed by Catarino, R.; Coelho, A.; Araújo, A.; Nogal, A.; Gomes, M.; Nogueira, A.; Medeiros, R.


Book ID
122048049
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
49 KB
Volume
7
Category
Article
ISSN
1359-6349

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Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr