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Expression of cyclin E and cyclin D1 in non-small cell lung cancers

โœ Scribed by Yamanouchi, Hideo; Furihata, Mutsuo; Fujita, Jiro; Murakami, Hiroshi; Yoshinouchi, Takeo; Takahara, Jiro; Ohtsuki, Yuji


Book ID
118569454
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
406 KB
Volume
31
Category
Article
ISSN
0169-5002

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Cyclin D1 and retinoblastoma susceptibil
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Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr