Expression and prognostic significance of cyclin B1 and cyclin A in non-small cell lung cancer
โ Scribed by Wendy A Cooper; Maija R J Kohonen-Corish; Brian McCaughan; Catherine Kennedy; Robert L Sutherland; Cheok Soon Lee
- Book ID
- 108780751
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 572 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0309-0167
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract High level of cyclin A promotes carcinogenesis, and overexpression of cyclin A has been associated with poor prognosis of cancer patients. We validated the prognostic role of cyclin A in gastric cancer and evaluated its correlation with expression of an mRNA stability factor HuR. From 3
Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr
## Flow cytometric cyclin expression/DNA content analysis, now commonly used, provides useful information on the mechanisms regulating cell cycle progression. However, this biparametric analysis does not make a clear-cut distinction between G 1 and S-early or between S-late and G 2 M phase cells.