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P-156 Expression of cyclins (A, B1, D1, D3 and E) in non-small cell lung cancers

โœ Scribed by Ha, Seung Yeon; Im, Jeong Soo; Choi, Jung Woo; Jung, Woon Yong; Lee, Ji-Hye; Shin, Bong Kyung; Kim, Han Kyeom

Book ID
118571857
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
346 KB
Volume
41
Category
Article
ISSN
0169-5002

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Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr