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Cyclin D1 in non-small cell lung cancer: A key driver of malignant transformation

✍ Scribed by Gautschi, Oliver; Ratschiller, Daniel; Gugger, Mathias; Betticher, Daniel C.; Heighway, Jim


Book ID
119319514
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
1008 KB
Volume
55
Category
Article
ISSN
0169-5002

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Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr