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Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer


Book ID
123187132
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
139 KB
Volume
12
Category
Article
ISSN
0169-5002

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Cyclin D1 and retinoblastoma susceptibil
โœ Antonio Marchetti; Claudio Doglioni; Mattia Barbareschi; Fiamma Buttitta; Silvia ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 256 KB ๐Ÿ‘ 2 views

Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr