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Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer


Book ID
123176040
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
172 KB
Volume
7
Category
Article
ISSN
0169-5002

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Cyclin D1 and retinoblastoma susceptibil
✍ Antonio Marchetti; Claudio Doglioni; Mattia Barbareschi; Fiamma Buttitta; Silvia πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 256 KB πŸ‘ 2 views

Among the major regulators of the G 1 restriction point are cyclin D1 and the retinoblastoma gene product (RB). In non-small cell lung cancer (NSCLC), the cyclin D1 gene is amplified/over-expressed in almost 50% of cases, and RB is inactivated in 6-32% of cases. It is of interest to evaluate concurr