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1H spectroscopic imaging of rat brain at 7 tesla

✍ Scribed by E. J. Fernandez; A. A. Maudsley; T. Higuchi; M. W. Weiner

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
770 KB
Volume
25
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

^1^H magnetic resonance spectroscopic imaging has been used to obtain metabolite maps of the rat brain. The spin‐echo‐based technique has been evaluated with respect to water and lipid suppression and sensitivity. Metabolite maps were constructed for choline. creatine + phosphocreatine, amino acids, Nacetyl aspartate, and lactate. A spatial resolution of 3 × 3 mm (in plane) with 7‐mm‐thick slices was achieved routinely in 60‐min (16 × 16 phase encoding) acquisitions. For higher intensity resonances, metabolite maps could be constructed in as little as 10 min. Results from phantoms and from rats under normal and focal ischemia conditions are presented.

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