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Evaluation of optimal echo time for 1H-spectroscopic imaging of brain tumors at 3 Tesla

✍ Scribed by Elke Hattingen; Ulrich Pilatus; Kea Franz; Friedhelm E. Zanella; Heinrich Lanfermann

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
346 KB
Volume
26
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To compare the spectral quality of short echo time (TE) MR spectroscopic imaging (MRSI, TE = 30 msec) with long‐TE MRSI (TE = 144 msec) at 3 Tesla in normal brain and tumor tissue.

Materials and Methods

Spectroscopic imaging (chemical‐shift imaging (CSI)) data of 32 patients with histopathological confirmed brain lesions were acquired at 3 Tesla (3T) using TEs of 30 msec and 144 msec. Tumor‐relevant metabolites (trimethylamine (TMA), creatine compounds (tCr), and N‐acetylated compounds (tNAA)) were analyzed with LCModel software, which applies prior knowledge by performing a frequency domain fit using a linear combination of model spectra.

Results

Short‐TE spectra provided up to twice the signal‐to‐noise ratio (SNR) compared to TE = 144 msec. The estimated fitting error was improved up to 30% for TMA and tCr, but was slightly reduced (10%) for tNAA. Quantification in terms of absolute concentrations was consistent at both TEs.

Conclusion

Since other metabolites observable at TE < 30 msec may be of diagnostic relevance, short‐TE MRSI should be the preferred method at 3T for the evaluation of focal lesions in brain tissue; however, TE = 144 msec can serve as an option for MRS in regions with potential baseline problems. J. Magn. Reson. Imaging 2007;26:427–431. © 2007 Wiley‐Liss, Inc.

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