✦ LIBER ✦

1H NMR spectroscopic imaging of the mouse brain at 9.4 T

✍ Scribed by Naoyuki Miyasaka; Kan Takahashi; Hoby P. Hetherington

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 680 KB
Volume: 24
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.20709

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✦ Synopsis

Abstract

Purpose

To assess the feasibility of ^1^H spectroscopic imaging (SI) in the mouse brain at 9.4 T, and investigate regional variations in brain metabolites.

Materials and Methods

A total of 21 SI studies were performed in CD‐1 mice to evaluate the basal ganglia (N = 5), hippocampus and thalamus (N = 11), and cerebellum (N = 5). We adjusted the B~0~ homogeneity for each slice using a fully automated shim calculation method based on the B~0~ map, which we measured using a multislice gradient‐echo sequence with multiple phase evolution delays. The SI employed a modified localization by adiabatic selective refocusing (LASER) sequence with TE/TR of 50/2000 msec, 24 × 24 encodes over a field of view (FOV) of 24 mm × 24 mm, 1 μL voxel resolution, and two averages, for a total acquisition time of 38 minutes.

Results

Sufficient shimming was achieved and high‐quality spectra were consistently obtained in each slice. N‐acetyl aspartate (NAA)/creatine (Cr) ratios in the basal ganglia and thalamus (0.86 ± 0.07, and 0.87 ± 0.07, respectively) were significantly higher than those in the hippocampus and cerebellum (0.76 ± 0.03 and 0.67 ± 0.07), which were also significantly different from each other.

Conclusion

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