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3D TrueFISP imaging of mouse brain at 4.7T and 9.4T

✍ Scribed by Sylvain Miraux; Philippe Massot; Emeline J. Ribot; Jean-Michel Franconi; Eric Thiaudiere

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
331 KB
Volume
28
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To examine the ability of TrueFISP imaging for evaluating tumor size in mouse brain at high field.

Materials and Methods

Brains of healthy and glioma‐implanted nude mice were imaged at 4.7T and 9.4T. 3D imaging was performed with TrueFISP and T2w‐RARE. Radiofrequency pulses with alternating phase and the sum‐of‐squares reconstruction method were used in TrueFISP imaging. The contrast‐to‐noise ratio (CNR) was evaluated in healthy and in tumoral brain regions.

Results

Banding artifact was correctly suppressed in TrueFISP images thanks to the method used. The signal‐to‐noise ratio (SNR) and CNR were comparable in TrueFISP and T2w‐RARE images at 4.7T, but acquisition was around 4 times shorter with TrueFISP. Tumor was well detected at 4.7T with TrueFISP, but CNR between tumor and healthy tissue was low at 9.4T.

Conclusion

TrueFISP is efficient and fast to perform brain imaging at 4.7T. Multiple TrueFISP acquisitions with phase‐cycled radiofrequency (RF) pulses and sum‐of‐squares reconstruction allow suppression of banding artifact. Tumoral regions were well detected and the method allows longitudinal studies of tumor growth. J. Magn. Reson. Imaging 2008;28:497–503. © 2008 Wiley‐Liss, Inc.

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