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2D 1H spectroscopic imaging of the human brain at 4.1 T

✍ Scribed by Hoby P. Hetherington; Jullie W. Pan; Graeme F. Mason; Steven L. Ponder; Donald B. Twieg; Georg Deutsch; James Mountz; Gerald M. Pohost

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
503 KB
Volume
32
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A two‐dimensional spectroscopic imaging sequence consisting of an inversion recovery pulse, a plane selective prefocused pulse, and a semiselective water suppression pulse has been used to create ^1^H spectroscopic images of the human brain with nominal voxels of 0.5 cc. Due to the excellent lipid suppression provided by the inversion recovery pulse and subsequent delay, only planar volume selection is required enabling the entire brain within the slice to be imaged without contamination from extracerebral lipids in the brain voxels. The use of a semiselective refocusing pulse for water suppression permits any echo evolution time to be used, minimizing J‐modulation and T~2~ losses, while retaining full sensitivity in the lactate resonance. Using this sequence we have visualized the lactate elevation in the peri‐infarct region about a 6‐week‐old stroke.

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