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3D 31P Spectroscopic Imaging of the Human Heart at 4.1 T

✍ Scribed by Hoby P. Hetherington; Derek J. E. Luney; J. Thomas Vaughan; Jullie W. Pan; Steven L. Ponder; Otmar Tschendel; Donald B. Twieg; Gerald M. Pohost

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
588 KB
Volume
33
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

High field (4 Tesla) spectroscopic imaging offers the advantages of increased signal‐to‐noise ratio and the possibility of acquiring high resolution metabolite images. We have applied a three dimensional spectroscopic imaging sequence using a sparse Gaussian sampling method to acquire phosphocreatine (PCr) images of the human heart with 8‐cc voxels. PCr images enabled observation of the septum, left ventricular free wall, apex, and skeletal muscle. Quantitative evaluation of the 50 myocardial voxels acquired from 10 studies of healthy adults revealed a PCr/adenosine triphosphate (ATP) ratio of 1.80 ± 0.32 after correction for saturation effects. Due to the small size of the voxels and the ability to choose the location of the volumes to minimize inclusion of blood, no correction for blood pool ATP was required. The calculated PCr/ATP ratio is in agreement with other studies at 1.5 and 4.0 T.

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