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Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T

✍ Scribed by Jullie W. Pan; Graeme F. Mason; Gerald M. Pohost; Hoby P. Hetherington

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 602 KB
Volume: 36
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910360103

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✦ Synopsis

Abstract

The authors report the development and implementation of a water‐suppressed J‐refocused coherence transfer sequence to observe glutamate in human brain at 4.1 T. The sequence is modeled for I~2~S~2~ and I~2~S~2~M spin systems analytically and plotted for a range of echo times. In this sequence, water suppression and refocusing of J‐coupled resonances are achieved through a brief multiple quantum step without significant loss of signal. Phantom data are shown. Human brain spectroscopic imaging of glutamate, acquired with a total echo of 36 ms, demonstrates the application of the sequence to observe gray and white matter differences in glutamate content.

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