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13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T

✍ Scribed by Jullie W. Pan; Graeme F. Mason; J. Thomas Vaughan; Wen-Jang Chu; Yantian Zhang; Hoby P. Hetherington

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 387 KB
Volume: 37
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910370308

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✦ Synopsis

Abstract

The method of single quantum ^13^C editing is analyzed and implemented with water suppressed J‐refocused coherence transfer spectroscopy. Analysis of the ^13^C inversion pulse demonstrates that it is optimally placed into the second echo of the J‐refocused sequence. We have used this method to acquire ^13^C‐edited spectra of glutamate from phantoms and in vivo. The turnover of ^13^C4‐labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.

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