Fast three-dimensional 1H MR spectroscopic imaging at 7 Tesla using “spectroscopic missing pulse – SSFP”

✍ Scribed by Christian Schuster; Wolfgang Dreher; Jörg Stadler; Johannes Bernarding; Dieter Leibfritz

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 596 KB
• Volume: 60
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.21787

✦ Synopsis

Abstract

The use of spectroscopic Missing Pulse ‐ SSFP (spMP‐SSFP) for fast three‐dimensional (3D) proton MR spectroscopic imaging (MRSI) at 7 Tesla (T) is demonstrated. Sequence modifications were required regarding the limits of the specific absorption rate as well as hardware limitations with respect to maximum B~1~ field strength and B~0~ gradient slew rate, as compared to previous studies performed at 3T. The combination of two spatially selective radiofrequency (RF) pulses (with orthogonal slice orientation) and a dual‐band chemical shift selective RF pulse for simultaneous water and lipid suppression proved to enable fast 3D MRSI measurements of the brain of healthy volunteers. Using a total measurement time of approximately 8.5 minutes and a nominal and real voxel size of 0.62 cm^3^ and 2.6 cm^3^, respectively, signals of N‐acetyl aspartate, total creatine, choline containing compounds, myo‐inositol, and glutamate+glutamine could be detected. Magn Reson Med, 2008. © 2008 Wiley‐Liss, Inc.