14C- and 2H-labelled 7-methylbenz[c]acridine
✍ Scribed by H. T. A. Cheung; G. M. Holder; L. Moldovan
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 304 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
7‐Methylbenz[c]acridine‐7‐^14^C, specific activity 12.2 mCi/mmole, and deuterated 7‐methylbenz[c]acridine were prepared from acetic anhydride‐1‐^14^C and aceticanhydride‐2‐^2^H~6~ respectively. The deuterated compound was not specifically labelled at the 7‐methyl group because isotopic exchange of the hydrogen atoms occurred during synthesis.
📜 SIMILAR VOLUMES
A synthesis of dibucaine labeled with l"C in the heterocyclic ring is described. starting with isatin and acetic anh~dride-2-~"C as shown in Scheme I. Two deutero analogs, dibucaine-d2 and dibucaine-dg, were also synthesized by the reactions shown in Scheme 11. Dibucaine-dg was synthesized by conden
## Abstract Deuterated and tritiated 7,9‐dimethylbenz [c] acridine, and 7,10‐dimethyl‐benz[c]acridine, labelled at the methyl groups, were prepared by catalytic dehalogenation of bromomethyl compouds. For each aza‐aromatic compound three brominated derivatives were prepared and characterized. Incor
## Abstract ^2^H and ^3^H labelled Sch 40120 were prepared by Pt catalysed exchange with isotopic water. D7‐Sch 40120 was obtained in two exchanges in 53% yield and ^3^H‐Sch 40120 was prepared by a single exchange at a specific activity of 19.8 Ci/mmole. ^14^C‐Sch 40120 was prepared in 4 steps from
## Abstract The cytotoxic antitumor compound PNU‐159548 (**1**) has been labelled with ^14^C and ^2^H. A three‐step sequence starting from [14‐^14^C]idarubicin (**2a**) led to radiochemically pure (>98%) [14‐^14^C]PNU‐159548 with a specific activity of 1.13 GBq/mmol. The synthesis of [^2^H~4~]PNU‐1
## Abstract [^3^H]SCH 211803, at a specific activity of 1.56 Ci/mmol, was prepared by direct exchange with tritiated water and platinum metal. [^2^H~4~]SCH 211803 was prepared from [^2^H]formaldehyde in a seven step synthesis in 10% yield. [^14^C]SCH 211803 was prepared from __N__‐benzyl‐4‐hydroxy[