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The preparation of 2H and 3H-labelled 7,9-, and 7,10-dimethylbenz[c]acridine by catalytic dehalogenation

✍ Scribed by Yuerong Ye; Gerald M. Holder; Colin C. Duke

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
422 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Deuterated and tritiated 7,9‐dimethylbenz [c] acridine, and 7,10‐dimethyl‐benz[c]acridine, labelled at the methyl groups, were prepared by catalytic dehalogenation of bromomethyl compouds. For each aza‐aromatic compound three brominated derivatives were prepared and characterized. Incorporation of deuterium occurred more readily at the 9‐ or 10‐methyl groups than the 7‐methyl groups suggesting a large isotope effect for catalytic deuteration.

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