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Synthesis of PNU-159548 labelled with 14C and 2H

✍ Scribed by C. Felicini; E. Fontana

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
99 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The cytotoxic antitumor compound PNU‐159548 (1) has been labelled with ^14^C and ^2^H. A three‐step sequence starting from [14‐^14^C]idarubicin (2a) led to radiochemically pure (>98%) [14‐^14^C]PNU‐159548 with a specific activity of 1.13 GBq/mmol. The synthesis of [^2^H~4~]PNU‐159548 was carried out in a similar manner starting from [1,1,2,2‐^2^H~4~]2‐bromoethanol (3b). Copyright © 2002 John Wiley & Sons, Ltd.

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