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α,α-Difluoroketone inhibitors of HMG CoA reductase

✍ Scribed by Geoffrey B. Dreyer; Brian W. Metcalf

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
241 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

The rationale for a new class of HMG CoA reductase inhibitors, represented by a,adifluoroketones 3 and 4, is described. The syntheses of 3,4, and their nonfluorinated analogue 5 are presented.

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