The absorption and disposition of fluvastatin have been studied in the female rabbit. In naive rabbits receiving a single oral dose (1 mg kg-I) of [3H]fluvastatin, absorption was rapid and amounted to c. 90 per cent compared with an intravenous reference dose. The drug was subject to considerable fi
Electrical myotonia of rabbit skeletal muscles by HMG-CoA reductase inhibitors
β Scribed by Dr. Yoshito Sonoda; Dr. Tsukasa Gotow; Dr. Masaru Kuriyama; Keiichi Nakahara; Kimiyoshi Arimura; Mitsuhiro Osame
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 640 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0148-639X
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Hydrogen atom abstraction rate constants for the reaction of tert-butoxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical with the HMG-CoA reductase inhibitors lovastatin, simvastatin, and statins I-IV were measured. This series of diene-containing drugs is known to be prone to oxidation. The tert-
Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron