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α-Synuclein protects SH-SY5Y cells from dopamine toxicity

✍ Scribed by Monica Colapinto; Silvia Mila; Sabrina Giraudo; Paola Stefanazzi; Monica Molteni; Carlo Rossetti; Bruno Bergamasco; Leonardo Lopiano; Mauro Fasano

Book ID
116293615
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
207 KB
Volume
349
Category
Article
ISSN
0006-291X

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## Abstract Free cytoplasmic dopamine may be involved in the genesis of neuronal degeneration in Parkinson's disease and other such diseases. We used SH‐SY5Y human neuroblastoma cells to study the effect of dopamine on cell death, activation of stress‐induced pathways, and expression of α‐synuclein