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Dopamine facilitates α-synuclein oligomerization in human neuroblastoma SH-SY5Y cells

✍ Scribed by Kentaro Yamakawa; Yasuhiko Izumi; Hiroki Takeuchi; Noriyuki Yamamoto; Toshiaki Kume; Akinori Akaike; Ryosuke Takahashi; Shun Shimohama; Hideyuki Sawada

Book ID
116299443
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
908 KB
Volume
391
Category
Article
ISSN
0006-291X

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## Abstract Free cytoplasmic dopamine may be involved in the genesis of neuronal degeneration in Parkinson's disease and other such diseases. We used SH‐SY5Y human neuroblastoma cells to study the effect of dopamine on cell death, activation of stress‐induced pathways, and expression of α‐synuclein