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α-Synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells

✍ Scribed by Fengxia Wu; Wai Sang Poon; Gang Lu; Ancong Wang; Haiwei Meng; Lei Feng; Zhenping Li; Shuwei Liu


Book ID
113504441
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
674 KB
Volume
1292
Category
Article
ISSN
0006-8993

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## Abstract Uncoupling proteins (UCPs) uncouple oxidative phosphorylation from ATP synthesis by dissipating proton gradient across mitochondrial inner membrane. The physiological role of neuronal specific UCP5 is unknown. We explored the effects of reduced UCP5 expression on mitochondrial membrane