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Über Pterinchemie. 44. Mitteilung. Eine eindeutige Synthese isomerenfreier Folsäure

✍ Scribed by Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1973
Tongue
German
Weight
429 KB
Volume
56
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A new, simplified and unequivocal synthesis of folic acid free of isomers is described. A melt of N(2′)‐acetyl‐6‐formylpterine and dimethyl‐N‐(p‐aminobenzoyl)‐L‐glutamate was quantitatively converted to 6‐azomethin‐pterine‐ester IV. NaBH~4~‐reduction followed by basic hydrolysis of acetyl and ester groups gives pure folic acid in good yield.

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