𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Über Pterinchemie. 60. vorläufige Mitteilung [1]. Eine neue, regiospezifische Synthese von L-Biopterin

✍ Scribed by Bernhard Schircks; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1977
Tongue
German
Weight
178 KB
Volume
60
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

A new, regiospecific synthesis of L‐biopterine

Pure L‐biopterine (I) is obtained in 35–40% yield by condensation of 5‐desoxy‐L‐arabinose‐hydrazone acetate with 2,4,5‐triamino‐6‐hydroxy‐pyrimidine, followed by oxidation of the formed tetrahydro‐derivative and deacetylation of the L‐bioterine diacetate. Catalytic reduction of the L‐biopterine gives the expected mixture of two diastereomeric tetrahydro‐L‐biopterines.

📜 SIMILAR VOLUMES

Uber Pterinchemie. 41. Mitteilung [1]. E
Uber Pterinchemie. 41. Mitteilung [1]. Eine neue Synthese von D, L-Biopterin
✍ M. Viscontini; W. F. Frei 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 German ⚖ 373 KB

## Abstract – Die Kondensation von D, L‐2,3‐O‐Isopropyliden‐4‐methyl‐erythrulose mit 2,4,5‐Triamino‐6‐hydroxypyrimidin wird beschrieben. Die Luft‐Oxydation des hydrierten Kondensationsproduktes führt zu D, L‐1′,2′‐O‐Isopropyliden‐biopterin ohne Abspaltung der Seitenkette. Durch hydrolytische Abspal

Über Pterinchemie 76. Mitteilung [1] Ein
Über Pterinchemie 76. Mitteilung [1] Eine einfache Synthese von Leucovorin
✍ Esam Khalifa; Abhoy N. Ganguly; Jost H. Bieri; Max Viscontini 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 German ⚖ 307 KB

**A Convenient Synthesis of Leucovorin** The synthesis of leucovorin, a 5‐formyl‐(6__R__ or __S__)‐5,6,7,8‐tetrahydropteroyl‐L‐glutamic acid (II) is described. The L‐folic acid was first reduced to (6__R__, __S__)‐tetrahy‐dro‐L‐folic acid (I); formylation with methyl‐formate in DMSO gave directly l