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Über Pterinchemie. 54. Mitteilung [1]. Eine allgemeine Methode zur Synthese von Folsäure, Folsäurekonjugaten und Folsäureanalogen

✍ Scribed by Esam Khalifa; Pradip K. Sengupta; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1976
Tongue
German
Weight
370 KB
Volume
59
Category
Article
ISSN
0018-019X

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✦ Synopsis

A general method for synthesis of folic acid, its conjugates and analogues.

A new and general method for the synthesis of folic acid, folic acid conjugates and folic acid analogues is described. The key step, i.e. the condensation of N(2′)‐acetyl‐6‐formyl‐pterine (I: R^1^  COCH~3~) with aminoaryl derivatives II, is achieved by refluxing in absolute ethanol to afford the azomethines III. NaBH~4~‐reduction followed by basic hydrolysis gives pure V products in high yield, free from 7‐isomers.

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