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Über Pterinchemie. 68 Mitteilung [1]. Regiospezifische Deuterierungen von Folsäure

✍ Scribed by Esam Khalifa; Hans-Jürg Furrer; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1978
Tongue
German
Weight
236 KB
Volume
61
Category
Article
ISSN
0018-019X

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✦ Synopsis

Regiospecific deuteriation of folic acid

Introduction of a nitroso function at the N (10)‐position of folic acid activates the C(9)‐hydrogen atoms in such a way, that the exchange of H with D at this position, in NaOD‐solution, is extremely facilitated. This fact is utilized in the synthesis of 9,9‐dideuterio‐folic acid (IV), 7,9,9‐trideuterio‐folic acid (VII) and 7‐deuterio‐folic acid (IX). These three products are necessary for the ^1^H‐NMR.‐spectroscopical determination of the conformation of 5,6,7,8‐tetrahydrofolic acid and its derivatives.

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