The idea of using hematoporphyrin or hematoporphyrin derivative (HPD) in combination with light as a diagnostic and/or therapeutic modality for human cancer dates back to published work in the early 1960s. Lipson and Baldes [l] described the photodynamic properties of a hematoporphyrin derivative in
Zinc hematoporphyrin in preparations of hematoporphyrin and hematoporphyrin derivative
β Scribed by A.A. Lamola; M. Sassaroli
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 325 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0009-2614
No coin nor oath required. For personal study only.
β¦ Synopsis
Tbc blue-sbilicd emission from aged ~~IICOUS SO~II~~OIIS of hcmatoporphyrin and its derivatives. reporred by others to origimtc from special~ggrcg.!tcs, isshown to originate from the zinc chelates of the porphyrins. Sagestions arc made regxding the role of such zmc porphyrins in the localization of hematoporphyrin and its derivatives in tumors.
π SIMILAR VOLUMES
Illumination of hematoporphyrin diacetate (HP-Diac) and hematoporphyrin (HP) in phosphate-buffered solutions causes the formation of a stable photoproduct absorbing at 636 nm. Simultaneously the photo-oxidation of HP-Diac and HP takes place. These phototransformations depend on the illumination dose
Tissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) H P D uptake, (2) H P D washout, and (3) fluorescence changes. The absorption peaks were the same for H P D in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10
Different fluorescence spectra are observed on preferential excitation of monomer and aggregate species of hematoporphyrin and hematoporphyrindiacetate, respectively. From these measurements we obtain the fluorescence spectrum of aggregate species in buffer solution, which shows two maxima, at 628 n
A new photoaclrvatron mechamsm of hcmatoporphyrin dcrivatrvc IS presented This process, based on the scqucntral ab. sorption of two photons, leads to the production of cytotoxrc radicals of HpD. The cytocrdal efficnency is dcmonstmted by in vitro experiments.