The selective excitation of high lying singlet or triplet states of hematoporphyrin has been achieved using high peak-power nanosecond pulses generated by excimer-pumped dye lasers. The interaction involves two steps: a pulse at 630 nm raises the molecules to the S1 state and a second one, at 481 nm
Two-step laser activation of hematoporphyrin derivative
β Scribed by A. Andreoni; R. Cubeddu; S. De Silvestri; P. Laporta; O. Svelto
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 229 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0009-2614
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β¦ Synopsis
A new photoaclrvatron mechamsm of hcmatoporphyrin dcrivatrvc IS presented This process, based on the scqucntral ab. sorption of two photons, leads to the production of cytotoxrc radicals of HpD. The cytocrdal efficnency is dcmonstmted by in vitro experiments.
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