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W01.2 Toll-like receptor 4 is involved in the regulation of vascular remodeling

✍ Scribed by Quax, P.; de Vries, M.; Vink, A.; Schepers, A.; Eefting, D.; Pires, N.; Jukema, W.; van Bockel, H.; de Kleijn, D.


Book ID
118632397
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
137 KB
Volume
5
Category
Article
ISSN
1567-5688

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Toll-like receptor 4 is involved in the
✍ Takehiko Uesugi; Matthias Froh; Gavin E. Arteel; Blair U. Bradford; Ronald G. Th πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 394 KB

Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc