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Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

✍ Scribed by Divanovic, Senad; Trompette, Aurelien; Atabani, Sowsan F; Madan, Rajat; Golenbock, Douglas T; Visintin, Alberto; Finberg, Robert W; Tarakhovsky, Alexander; Vogel, Stefanie N; Belkaid, Yasmine


Book ID
109922065
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
454 KB
Volume
6
Category
Article
ISSN
1529-2908

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Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n