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TOLL-LIKE RECEPTOR 4 IS INVOLVED IN THE REGULATION OF VASCULAR REMODELING

✍ Scribed by Paul Quax; Margreet de Vries; Aryan Vink; Abbey Schepers; Daniel Eefting; Nuno Pires; Wouter Jukema; Hajo van Bockel; Dominique de Kleijn


Book ID
116342158
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
38 KB
Volume
13
Category
Article
ISSN
1054-8807

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Toll-like receptor 4 is involved in the
✍ Takehiko Uesugi; Matthias Froh; Gavin E. Arteel; Blair U. Bradford; Ronald G. Th πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 394 KB

Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc