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Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice

✍ Scribed by Takehiko Uesugi; Matthias Froh; Gavin E. Arteel; Blair U. Bradford; Ronald G. Thurman

Book ID
111721540
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
394 KB
Volume
34
Category
Article
ISSN
0270-9139

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Toll-like receptor 4 is involved in the
Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
✍ Takehiko Uesugi; Matthias Froh; Gavin E. Arteel; Blair U. Bradford; Ronald G. Th πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 394 KB

Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc