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725 ROLE OF TOLL-LIKE RECEPTOR 4 IN THE DEVELOPMENT OF FRUCTOSE-INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE IN MICE

โœ Scribed by A. Spruss; G. Kanuri; S. Wagnerberger; S. Weber; S.C. Bischoff; I. Bergheim


Book ID
117377732
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
47 KB
Volume
50
Category
Article
ISSN
0168-8278

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โœ Takehiko Uesugi; Matthias Froh; Gavin E. Arteel; Blair U. Bradford; Ronald G. Th ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 394 KB

Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc