Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays
✍ Scribed by Cheng. Yung-Chi; Raymond F. Schinazi; Ginger E. Dutschman; Tan Reng-Seng; Susan P. Grill
- Book ID
- 119113995
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 714 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0166-0934
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📜 SIMILAR VOLUMES
A simple method to determine the in vitro catalytic turnover constant of several substrates of herpes simplex virus type 1 thymidine kinase is presented in this study. The method is based on a continuous spectroscopic enzyme-coupled assay and allows one to monitor the herpes simplex virus type 1 thy
## Abstract We previously isolated an acyclovir (ACV)‐resistant herpes simplex virus type 1 (HSV‐1), strain TAR, from a child with Wiskott‐Aldrich syndrome. An acyclovir‐sensitive HSV‐1, strain TAS, had been isolated from the same patient before the isolation of HSV‐1 TAR. The TK protein of ACV‐sen