Gene therapy for colon cancer with the h
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Link, Charles J.; Levy, John P.; McCann, Leisa Z.; Moorman, Donald W.
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Article
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1997
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John Wiley and Sons
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English
β 74 KB
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## Background: The suicide gene and prodrug, herpes simplex thymidine kinase (hstk) and ganciclovir (gcv), are now in clinical trials for recurrent malignancies. ## Methods: We evaluated in vitro and in vivo efficacy of hstk gene transfer and gcv treatment of colonic adenocarcinoma in a syngeneic