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Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer

✍ Scribed by Waleed Hassan; Michael A. Sanford; Savio L. C. Woo; Shu-Hsia Chen; Simon J. Hall


Book ID
106033849
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
305 KB
Volume
18
Category
Article
ISSN
0724-4983

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## Background: The suicide gene and prodrug, herpes simplex thymidine kinase (hstk) and ganciclovir (gcv), are now in clinical trials for recurrent malignancies. ## Methods: We evaluated in vitro and in vivo efficacy of hstk gene transfer and gcv treatment of colonic adenocarcinoma in a syngeneic