Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase
β Scribed by Hattori, Yoshiyuki; Maitani, Yoshie
- Book ID
- 110019247
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 499 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0929-1903
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSVβTK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea
It is critical to develop new therapies, such as gene therapy, which can impact on both local and metastatic prostate cancer progression. We have developed an orthotopic mouse model of metastatic prostate cancer using a cell line (RM-1) derived from the mouse prostate reconstitution (MPR) model syst