Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer
β Scribed by Hall, Simon J; Mutchnik, Steven E; Yang, Guang; Timme, Terry L; Nasu, Yasutomo; Bangma, Chris H; Woo, Savio L C; Shaker, Mohammed; Thompson, Timothy C
- Book ID
- 110017602
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 540 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0929-1903
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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSVβTK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea