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Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy

✍ Scribed by Park, J Y; Elshami, A A; Amin, K; Rizk, N; Kaiser, L R; Albelda, S M


Book ID
110038053
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
519 KB
Volume
4
Category
Article
ISSN
0969-7128

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea