In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma
β Scribed by Rosolen, A; Frascella, E; Francesco, C di; Todesco, A; Petrone, M; Mehtali, M; Zacchello, F; Zanesco, L; Scarpa, M
- Book ID
- 110038123
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 155 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0969-7128
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently in
Currently, there is no effective treatment for pancreatic cancer and prodrug-activating gene therapy with the herpes simplex virus thymidine kinase gene (HSV-tk) in combination with ganciclovir (GCV) has been suggested as a candidate approach against this disease. In the present study, we have evalu