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Gene therapy for glioblestome multiforme: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir

✍ Scribed by G. Stockhammer; J. Brotchi; R. Leblanc; M. Bernstein; G. Schackert; F. Weber; C. Ostertag; N. H. Mulder; H. Mellstedt; R. Seiler; Y. Yonekawa; K. Twerdy; H. Kostron; O. De Witte; M. Lambermont; T. Velu; P. Laneuville; J.-G. Villemure; J. T. Rutka; P. Warnke; M. Laseur; J. J. A. Mooij; J. Boëthius; L. Mariani; M. Meyer; C. Brändli; K. Frei; D. Könu; A. Gianella-Borradori


Publisher
Springer
Year
1997
Tongue
English
Weight
112 KB
Volume
75
Category
Article
ISSN
0946-2716

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea