In vivo enhancement of herpes simplex vi
β
Tiina Wahlfors; Tanja Hakkarainen; Juhani JΓ€nne; Leena Alhonen; Jarmo Wahlfors
π
Article
π
2006
π
John Wiley and Sons
π
French
β 150 KB
## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSVβTK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea