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Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy

✍ Scribed by Boucher, P D; Ostruszka, L J; Murphy, P J M; Shewach, D S


Book ID
110039074
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
170 KB
Volume
9
Category
Article
ISSN
0969-7128

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea