Variation of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma
β Scribed by Jonathon F. Parkinson; Helen R. Wheeler; Adele Clarkson; Catriona A. McKenzie; Michael T. Biggs; Nicholas S. Little; Raymond J. Cook; Marinella Messina; Bruce G. Robinson; Kerrie L. McDonald
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 317 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0167-594X
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## Abstract Promotor hypermethylation is a common event in human cancer. __O^6^βMethylguanineβDNA Methyltransferase__ (__MGMT__) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of __MGMT__ has been correlated
Repair of cytotoxic DNA damage by O 6 -methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear