Epigenetic silencing of O 6 -methylguanine-DNA methyltransferase (MGMT) by promoter methylation can confer cancer cells with an increased sensitivity to alkylating chemotherapeutic agents and a higher susceptibility to TP53 transition mutations. The aim of our study was to assess the correlation of
O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications
β Scribed by Shin-Hyuk Kang; Kyung-Jae Park; Chae-Yong Kim; Mi Ok Yu; Chul-Kee Park; Sung-Hye Park; Yong-Gu Chung
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 714 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0167-594X
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## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^βmethylguanineβDNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu
## Abstract O^6^βmethylguanineβDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationβspecific PCR (MSP)