𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The promoter methylation status of the DNA repair geneO6-methylguanine-DNA methyltransferase in ulcerative colitis

✍ Scribed by Shunji Matsumura; Naohide Oue; Reiko Ito; Hirofumi Nakayama; Yasuhiko Kitadai; Hiroshi Yokozaki; Kazuaki Chayama; Wataru Yasui


Publisher
Springer
Year
2003
Tongue
English
Weight
226 KB
Volume
443
Category
Article
ISSN
1432-2307

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Methylation of selected CpGs in the huma
✍ Rebecca Prapurna Danam; Xilin C. Qian; Sherie R. Howell; Thomas P. Brent πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 116 KB πŸ‘ 1 views

O 6 -Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20-30% of human tumor lines is tightly linked to methylati

Methylation pattern of the O6-methylguan
✍ Takeshi Nagasaka; Ajay Goel; Kenji Notohara; Takaomi Takahata; Hiromi Sasamoto; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 French βš– 635 KB

## Abstract __O__^6^‐methylguanine‐DNA methyltransferase (__MGMT__) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within __MGMT__ promoter leads to loss of its protein expression, and i