The promoter methylation status of the DNA repair geneO6-methylguanine-DNA methyltransferase in ulcerative colitis
β Scribed by Shunji Matsumura; Naohide Oue; Reiko Ito; Hirofumi Nakayama; Yasuhiko Kitadai; Hiroshi Yokozaki; Kazuaki Chayama; Wataru Yasui
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 226 KB
- Volume
- 443
- Category
- Article
- ISSN
- 1432-2307
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
O 6 -Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20-30% of human tumor lines is tightly linked to methylati
## Abstract __O__^6^βmethylguanineβDNA methyltransferase (__MGMT__) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within __MGMT__ promoter leads to loss of its protein expression, and i