Malignant melanoma is well known for its primary unresponsiveness to chemotherapy. The mechanisms conferring this intrinsic resistance are unclear. In this study, we investigated the role of genes involved in DNA repair in a panel of human melanoma cell variants exhibiting low and high levels of res
Intracellular localization and intercellular heterogeneity of the human DNA repair protein O6-methylguanine-DNA methyltransferase
β Scribed by M. Belanich; Terri Randall; Monica A. Pastor; Jeannie T. Kibitel; Lori Green Alas; M. Eileen Dolan; S. Clifford Schold Jr.; Marc Gander; Ferdy J. Lejeune; Benjamin F. L. Li; Agnes B. White; Patricia Wasserman; Marc L. Citron; Daniel B. Yarosh
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 496 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract O^6^βmethylguanineβDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationβspecific PCR (MSP)
O 6 -Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20-30% of human tumor lines is tightly linked to methylati
## Abstract The DNA repair enzyme O^6^βmethylguanineβDNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG