Quantitative analysis of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas
β Scribed by Adrian F. Ochsenbein; Adrian D. Schubert; Erik Vassella; Luigi Mariani
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 357 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^βmethylguanineβDNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu
## Abstract The use of molecular markers in the diagnostics of gliomas aids histopathological diagnosis and allows their further classification into clinically significant subgroups. The aim of this study was to characterize the methylation pattern of the O^6^βmethylguanineβDNA methyltransferase (_